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Canine tumours that spread by contagion are genetically almost identical from dog to dog, gene sequencing has shown. The genome sequence of a contagious cancer suggests that it emerged in an ancient breed of dog some 11, years ago and spread around the globe around the time of Christopher Columbus.

Canine transmissible venereal tumour CTVT is typically transferred during sex and appears as an ulcerous, rose-coloured protrusion on the genitals of dogs see picture at reader's discretiondue to its graphic nature. Tumours are masses of mutated cells that evolve ways to trick the immune system and proliferate unchecked.

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Normally, those tricks do not work if the cells are transplanted into another organism, Redd they are quickly recognized as foreign and destroyed.

However, in the Russian veterinarian M.

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Novinsky discovered that he could transplant CTVT tumours from one dog to another. Their cells would evade the new host's immune system and continue growing — a phenomenon previously unknown in the world of cancer biology.

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Although Czech girls talking about sex tumours have been transmitted during organ transplantation or from a mother to a fetus, the only other naturally occurring contagious tumour known occurs in Tasmanian devils. To understand this evolutionary process, Murchison and her colleagues selected two tumours for sequencing that would have had the opportunity to diverge for as long as possible: The two tumour genomes proved remarkably similar, and Murchison estimates that their most recent common ancestor occurred just years ago.

This suggests that CTVT remained in an isolated population of Free pussy Red Devil Alaska n j for most of its history, then something happened that allowed it to move into m dog populations and spread around the Alxska.

The genome of CTVT will be of interest to a wide range of cancer biologists. Unlike typical cancers, which usually involve several genetic lineages of cancerous cells competing with one another, every cell in the CTVT tumours had approximately the same genetic make-up.

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The genome contained a total of 1. Murchison, E.

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What matters in science — and why — free in your inbox every weekday. Our award-winning show features highlights from the week's edition of Natureinterviews with the people behind the science, and in-depth commentary and analysis from journalists around the world.

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References Murchison, E. Related stories and links From nature.

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